Pesquisar neste blogue

quinta-feira, 1 de maio de 2014

An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss

BIOMATERIALS
  1. Stephen F. Badylak1,2,
  1. 1McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  2. 2Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  3. 3Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  4. 4Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  5. 5Department of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  6. 6Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
  1. Corresponding author. E-mail: badylaks{at}upmc.edu
  • * These authors contributed equally to this work.

Abstract

Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. The ECM-mediated constructive remodeling was associated with stimulus-responsive skeletal muscle in rodents and functional improvement in three of the five human patients.

Sem comentários:

Enviar um comentário

Gostou do meu Blog? Envie a sua opinião para lmbgouveia@gmail.com