- Brian M. Sicari1,2,*,
- J. Peter Rubin1,3,4,*,
- Christopher L. Dearth1,2,
- Matthew T. Wolf1,4,
- Fabrisia Ambrosio1,5,
- Michael Boninger1,4,5,
- Neill J. Turner1,2,
- Douglas J. Weber4,5,
- Tyler W. Simpson5,
- Aaron Wyse6,
- Elke H. P. Brown5,
- Jenna L. Dziki1,4,
- Lee E. Fisher5,
- Spencer Brown1,3 and
- Stephen F. Badylak1,2,†
- 1McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
- 2Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
- 3Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
- 4Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA.
- 5Department of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15219, USA.
- 6Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
- ↵†Corresponding author. E-mail: badylaks{at}upmc.edu
Abstract
Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. The ECM-mediated constructive remodeling was associated with stimulus-responsive skeletal muscle in rodents and functional improvement in three of the five human patients.
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