Automated gait rehabilitation with LYRA explained

Automated Gait Therapy is backed by 20 Years of Research.

Please see a selection of notable papers and clinical studies below:

Stroke

• Jorgensen, H. S., Nakayama, H., Raaschou, H. O. & Olsen, T. S. Recovery of walking function in stroke patients: The Copenhagen stroke study. Arch. Phys. Med. Rehabil. 76, 27–32 (1995).
• Halder, P. et al. Electrophysiological evidence for cortical plasticity with movement repetition. Eur. J. Neurosci. 21,2271–2277 (2005).
• Peurala, S. H. et al. Effects of intensive therapy using gait trainer or floor walking exercises early after stroke. J. Rehabil. Med. 41, 166–173 (2009).
• Pohl, M. et al. Repetitive locomotor training and physiotherapy improve walking and basic activities of daily living after stroke: a single-blind, randomized multicentre trial (DEutsche GAngtrainerStudie, DEGAS). Clin. Rehabil. 21, 17–27 (2007).
• Dobkin, B. H. Strategies for stroke rehabilitation. Lancet Neurol. 3, 528–536 (2004).
• O’Dell, M. W., Lin, C.-C. D. & Harrison, V. Stroke rehabilitation: strategies to enhance motor recovery. Annu. Rev. Med.60, 55–68 (2009).
• Kwakkel, G., Kollen, B. & Lindeman, E. Understanding the pattern of functional recovery after stroke: facts and theories. Restor. Neurol. Neurosci. 22, 281–299 (2004).
• Mehrholz, J., Pohl, M. & Elsner, B. Treadmill training and body weight support for walking after stroke. Cochrane database Syst. Rev. 1, CD002840 (2014).
• Mehrholz, J., Elsner, B., Werner, C., Kugler, J. & Pohl, M. Electromechanical-assisted training for walking after stroke.Cochrane database Syst. Rev. 7, CD006185 (2013).

Spinal Cord Injury

• Winchester, P. et al. Changes in supraspinal activation patterns following robotic locomotor therapy in motor-incomplete spinal cord injury. Neurorehabil. Neural Repair 19, 313–324 (2005).
• Mehrholz, J. et al. Locomotor training for walking after spinal cord injury ( Review ) Locomotor training for walking after spinal cord injury. (2012). doi:10.1002/14651858.CD006676.pub3.Copyright

Parkinsons Disease

• Picelli, A. et al. Does robotic gait training improve balance in Parkinson’s disease? A randomized controlled trial.Parkinsonism Relat. Disord. 18, 990–993 (2012).
• Picelli, a. et al. Robot-Assisted Gait Training in Patients With Parkinson Disease: A Randomized Controlled Trial.Neurorehabil. Neural Repair 26, 353–361 (2012).
• Picelli, A. et al. Robot-assisted gait training versus equal intensity treadmill training in patients with mild to moderate Parkinson’s disease: A randomized controlled trial. Park. Relat. Disord. 19, 605–610 (2013).
• Sale, P. et al. Robot-assisted walking training for individuals with Parkinson’s disease: a pilot randomized controlled trial. BMC Neurol. 13, 50 (2013).

Multiple Sclerosis

• Swinnen, E. et al. Treadmill Training in Multiple Sclerosis: Can Body Weight Support or Robot Assistance Provide Added Value? A Systematic Review. Mult. Scler. Int. 2012, 1–15 (2012).
• Gandolfi, M. et al. Robot-assisted vs. sensory integration training in treating gait and balance dysfunctions in patients with multiple sclerosis: a randomized controlled trial. Front. Hum. Neurosci. 8, 318 (2014).
• Vaney, C. et al. Robotic-Assisted Step Training (Lokomat) Not Superior to Equal Intensity of Over-Ground Rehabilitation in Patients With Multiple Sclerosis. Neurorehabil. Neural Repair 26, 212–221 (2012).
• Lo, A. C. & Triche, E. W. Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training. Neurorehabil. Neural Repair 22, 661–671 (2008).
• Schwartz, I. et al. Robot-assisted gait training in multiple sclerosis patients: a randomized trial. Mult. Scler. 18, 881–890 (2012).
• Beer, S. et al. Robot-assisted gait training in multiple sclerosis: a pilot randomized trial. Mult. Scler. 14, 231–236 (2008).

Cerebral Palsy

• Druzbicki, M. et al. Functional effects of robotic-assisted locomotor treadmill therapy in children with cerebral palsy.J. Rehabil. Med. 45, 358–363 (2013).
• Smania, N. et al. Improved gait after repetitive locomotor training in children with cerebral palsy. Am. J. Phys. Med. Rehabil. 90, 137–149 (2011).

Traumatic Brain Injury

• Freivogel, S., Mehrholz, J., Husak-Sotomayor, T. & Schmalohr, D. Gait training with the newly developed ‘LokoHelp’-system is feasible for non-ambulatory patients after stroke, spinal cord and brain injury. A feasibility study. Brain Inj.22, 625–632 (2008).
• We are currently looking for clinical partners to further investigate the effects of automated gait therapy with patients after traumatic brain injury! Contact us to learn more.

Other

• Courtine, G. et al. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.Nat. Neurosci. 12, 1333–1342 (2009).
• Shadmehr, R. & Mussa-Ivaldi, F. a. Adaptive representation of dynamics during learning of a motor task. J. Neurosci.14, 3208–3224 (1994).
• Hömberg, V. Evidence based medicine in neurological rehabilitation–a critical review. Acta Neurochir. Suppl. 93, 3–14 (2005).
• Freivogel, S., Schmalohr, D. & Mehrholz, J. Improved walking ability and reduced therapeutic stress with an electromechanical gait device. J. Rehabil. Med. 41, 734–739 (2009)